The Effects of Oral Intake of Reduced Coenzyme Q10 (Ubiquinol) on Skin Conditions in Healthy Japanese Women
Oral ubiquinol enhanced skin moisture and cell quality, demonstrating visible anti-ageing effects in healthy women.
Research
Usefulness of regular intake of the reduced form of CoQ10 for stress management for workers
Regular Ubiquinol intake improved stress markers and work engagement in nurses, indicating benefits for workplace stress management.
The Effectiveness of Coenzyme Q10 (Ubiquinol) on the Quality of Life in Postmenopausal Women
Ubiquinol improved menopausal symptoms, mood, skin condition, and overall wellbeing compared to controls over a 3-month period.
Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Year of Publication: 2022 Journal: Frontiers in Pharmacology Authors: Tsai IC, et al. Type of Study: Systematic review and meta-analysis
Effects of Ubiquinol Intake and Sociophysical Training on Psychological and Physiological Markers
Year of Publication: 2024 Journal: Applied Sciences Authors: Ota M, et al. Type of Study: Double-blind, randomised controlled crossover pilot
Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals
Ubiquinol intake reduced fatigue and improved recovery post-cognition in healthy individuals, especially with higher doses improving oxidative stress markers.
Effects of Ubiquinol Intake on Improving Menstrual Symptoms Among Female Healthcare Workers
Ubiquinol reduced menstrual symptoms and improved sleep quality, showing strong benefits for women over 36 years of age.
Reduced Form of Coenzyme Q10 Relieves Daily Life Stress and Improves Sleep Quality in Healthy Subjects
The study showed that Ubiquinol significantly improved stress and sleep quality in individuals with high baseline stress levels.
The Role of Nutrients in the Pathogenesis and Treatment of Migraine Headaches
Coenzyme Q10 and other nutrients may help prevent migraines by addressing mitochondrial dysfunction and oxidative stress pathways.
Antiageing Effects of Ubiquinone and Ubiquinol in a Senescence Model of Human Dermal Fibroblasts
Ubiquinol reversed senescence phenotype more effectively than ubiquinone; improved mitochondrial function and oxidative status.
Coenzyme Q10 Supplementation in Aging and Disease
Supplementation wit coenzyme Q10 may alleviate ageing symptoms and improve cardiovascular and inflammatory health via mitochondrial and antioxidant effects.
Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome
Ubiquinol-10 supplementation showed beneficial effects on autonomic and cognitive symptoms in chronic fatigue syndrome patients.
Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years
CoQ10, particularly ubiquinol, shows strong benefits in cardiovascular and fertility health; absorption remains a limiting factor.
Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease
Symptom improvement observed in Parkinson’s patients with wearing-off; ubiquinol-10 demonstrated a favourable safety and tolerability profile.
Coenzyme Q10 Supplementation – In Ageing and Disease
High-dose CoQ10 may improve mitochondrial and cardiovascular health, though bioavailability and long-term effects require further research.
Coenzyme Q10 Levels Associated With Cognitive Functioning and Executive Function in Older Adults
Plasma Coenzyme Q10 levels were significantly associated with cognitive and executive function in older adults, even after controlling variables.
CoQ10 and Aging
CoQ10 reduces oxidative stress and inflammation, potentially improving cardiovascular health and mitochondrial function in age-related diseases.
Coenzyme Q10 and Dementia: A Systematic Review
Systematic review showed mixed results on CoenzymeQ10’s effect on dementia.
The effects of ubiquinol (reduced form of coenzyme Q10) on memory, attentiveness and work processing ability in healthy middle-aged and elderly residents — A randomized, double-blind, placebo-controlled trial
Ubiquinol improved cognitive function, in healthy middle- aged and elderly individuals with significant gains in attentiveness and task performance.
Coenzyme Q10: The Potential Role in Female and Male Subfertility. A Narrative Review of RCTs and Controlled Clinical Trials
Ubiquinol Coenzyme Q10 shows potential to improve fertility markers in men and women by enhancing mitochondrial health and hormone balance.
Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrheic Patients
Ubiquinol enhanced FSH and LH levels in amenorrheic women, suggesting improved neuroendocrine regulation and ovarian function.
Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance
Ubiquinol with Clomiphene improved follicular development and ovulation in PCOS women resistant to Clomiphene Citrate.
Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing In Vitro Fertilization for Unexplained Infertility
Coenzyme Q10 and omega-3 supplementation significantly improved IVF pregnancy rates and reduced hormone use in unexplained infertility cases.
Effects of the Reduced Form of Coenzyme Q10 (Ubiquinol) on Semen Parameters in Men with Idiopathic Infertility
Ubiquinol improved sperm density, motility, and morphology in infertile men, showing sustained effects post-treatment.
Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure Among Patients With Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (Grade)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials
This meta-analysis shows CoQ10 at 100–200 mg/day reduces systolic blood pressure, especially in diabetes, dyslipidemia, and longer-duration trials.
Effect of Ubiquinol Therapy on Sperm Parameters and Serum Testosterone Levels in Oligoasthenozoospermic Infertile Men
Six months of Ubiquinol improved sperm count, motility, morphology, and testosterone levels in men with oligoasthenozoospermia.
Combining Ubiquinol With a Statin May Benefit Hypercholesterolaemic Patients With Chronic Heart Failure.
This paper discusses the potential of combining ubiquinol with statins in heart failure patients to address muscle injury and energy loss.
Statin-Associated Cardiomyopathy Responds to Statin Withdrawal and Administration of Coenzyme Q10
This observational study shows improvement in cardiac function after statin withdrawal and ubiquinol supplementation in statin-associated cardiomyopathy patients.
Ubiquinol Rescues Simvastatin-Suppression of Mitochondrial Content, Function and Metabolism: Implications for Statin-Induced Rhabdomyolysis.
This study is an in vitro investigation showing how ubiquinol reverses simvastatin-induced mitochondrial dysfunction, restoring ATP and cell viability.
The Effect of Coenzyme Q10 in Statin Myopathy
Year of Publication: 2012 Journal: Neuro Endocrinol Lett Authors: Zlatohlavek L, Hutyra M, Braun M, Oravec S, Albahari P Type
Coenzyme Q10 and Ubiquinol as Adjunctive Therapy for Heart Failure
This paper reviews the role of ubiquinol as adjunct therapy in heart failure, emphasising absorption, bioavailability, and improved heart function
Myocardial Energetics and Ubiquinol in Diastolic Heart Failure
This review suggests ubiquinol could enhance energy metabolism in diastolic heart failure and calls for further controlled clinical trials.
Ubiquinol Improves Endothelial Function in Patients With Heart Failure With Reduced Ejection Fraction: A Single-Center, Randomized Double-Blind Placebo-Controlled Crossover Pilot Study
This study is a pilot RCT showing ubiquinol significantly improves endothelial function in patients with heart failure with reduced ejection fraction.
Association Between Serum Level of Ubiquinol and NT-proBNP, A Marker for Chronic Heart Failure, in Healthy Elderly Subjects
This observational study links higher ubiquinol levels to lower NT-proBNP, suggesting a protective cardiovascular role in healthy elderly individuals.
Influence of Ubiquinol on Angina Severity and Dyspnea in Patients with Acute Coronary Syndrome
This clinical trial demonstrates the effect of ubiquinol in reducing angina frequency and dyspnea, improving quality of life in ACS patients.
The Use of Coenzyme Q10 in Cardiovascular Diseases
This review outlines Coenzyme Q10’s cardiovascular benefits, highlighting its role in reducing oxidative stress, improving endothelial function, and supporting heart health.
Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
This RCT studied improvements in cardiac function or NT-proBNP after 4 months of CoQ10 in elderly HFpEF patients.
Coenzyme Q10 in the Treatment of Heart Failure with Preserved Ejection Fraction: A Prospective, Randomized, Double‑Blind, Placebo‑Controlled Trial
This RCT in HFpEF patients to study the benefits from CoQ10 supplementation in diastolic function or NT-proBNP levels.
Effect of Ubiquinol Supplementation on Biochemical and Oxidative Stress Indexes after Intense Exercise in Young Athletes
Ubiquinol reduces oxidative stress and prevents CoQ10 depletion post-exercise, but shows no significant impact on performance or muscle damage.
Effect of Ubiquinol Supplementation on Biochemical and Oxidative Stress Indexes after Intense Exercise in Young Athletes
Ubiquinol reduces oxidative stress, DNA damage, and lipid peroxidation during strenuous exercise, aiding recovery and vascular health in trained individuals.
Ubiquinol Supplementation Enhances Peak Power Production in Trained Athletes
Ubiquinol improves peak power output in trained athletes, offering performance gains beyond training alone during high-demand competitive preparation.
Faster Recovery after Exercise with Phytochemicals Aimed at Mitochondrial Energy Turnover
Phytochemical supplementation including coenzyme Q10 improved post-exercise recovery and fatigue resistance in female athletes by enhancing mitochondrial energy turnover.
Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage
Short-term ubiquinol use boosted muscle strength and protected against exercise-induced muscle damage in healthy, physically active men.
The Effects of Ubiquinol Supplementation on Clinical Parameters and Physical Performance of Trained Men
Six-week ubiquinol supplementation improved aerobic capacity and cardiovascular markers in trained men, indicating enhanced endurance and health parameters.
Coenzyme Q10 Supplementation and Its Impact on Exercise and Sport Performance in Humans: A Recovery or a Performance-Enhancing Molecule?
Coenzyme Q10 may enhance recovery and reduce oxidative stress, though its impact on performance remains inconsistent across studies.
Short-Term Ubiquinol-10 Supplementation Alleviates Tissue Damage in Muscle and Fatigue Caused by Strenuous Exercise in Male Distance Runners
Ubiquinol lowered enzyme markers of tissue damage and reduced perceived fatigue in distance runners during intensive summer training.
Short-Term Ubiquinol-10 Supplementation Alleviates Tissue Damage in Muscle and Fatigue Caused by Strenuous Exercise in Male Distance Runners
Ubiquinol lowered enzyme markers of tissue damage and reduced perceived fatigue in distance runners during intensive summer training.
Ubiquinol Supplementation Modulates Energy Metabolism and Bone Turnover During High-Intensity Exercise
Ubiquinol enhances bone turnover markers and energy metabolism during high-intensity exercise, potentially supporting muscular performance and recovery.
High Coenzyme Q10 Plasma Levels Improve Stress and Damage Markers in Professional Soccer Players During Competition
Higher plasma CoQ10 levels linked to lower muscle damage, improved kidney function, and better performance in elite soccer players.
Mitochondrial dysfunction in obesity: Potential benefit and mechanism of Coenzyme Q10 supplementation in metabolic syndrome
Coenzyme Q10 supports mitochondrial function, modulates inflammation, and may aid metabolic syndrome symptoms such as obesity and hypertension.