Mitochondrial and Metabolic Dysfunction in Ageing and Age-Related Diseases
Mitochondrial dysfunction is central to ageing and disease; improving mitochondrial health may extend lifespan and prevent degenerative conditions.
Research
The Key Role of Mitochondrial Function in Health and Disease
Mitochondrial health is vital in preventing chronic diseases; physical activity is the only proven way to enhance mitochondrial function.
Mitochondria at the Crossroads of Health and Disease
Mitochondria influence nearly all cellular processes, linking energy metabolism, disease progression, and ageing through dynamic signalling and structural adaptation
Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial
Ubiquinol reduces oxidative stress and prothrombotic markers in antiphospholipid syndrome, showing promise as adjunct therapy.
Coenzyme Q10 redox state predicts the concentration of C-reactive protein in a large Caucasian cohort
Ubiquinol improves redox status and may lower inflammation markers like CRP in individuals with low baseline CoQ10 levels.
The CoQH₂/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency
The CoQH₂/CoQ redox ratio regulates mitochondrial respiratory efficiency, adapting energy metabolism to nutrient and stress conditions.
Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency
Ubiquinol-10 effectively restores mitochondrial function and reduces brain pathology in a CoQ-deficient mouse model of encephalopathy.
Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
A clinical trial showing how ubiquinol enhances endothelial function in dyslipidemic patients by boosting nitric oxide and antioxidant response.
Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement
This comprehensive review outlines clinical benefits of Coenzyme Q10 in heart failure, focusing on improved prognosis, dosage, and long-term outcomes.
Association Between Serum Level of Ubiquinol and Nt-Probnp, a Marker for Chronic Heart Failure, in Healthy Elderly Subjects
This observational study links higher ubiquinol levels to lower NT-proBNP, suggesting a protective cardiovascular role in healthy elderly individuals.
Ubiquinol Effect on Sperm Parameters in Subfertile Men Who Have Asthenoteratozoospermia with Normal Sperm Concentration
Ubiquinol enhanced sperm motility and morphology in subfertile men with idiopathic infertility and normal sperm concentration.
Predictors of Pregnancy and Time to Pregnancy in Infertile Men with Idiopathic Oligoasthenospermia Pre- and Post-Coenzyme Q10 Therapy
Coenzyme Q10 improved sperm quality, antioxidant status, and predicted pregnancy outcomes in men with idiopathic oligoasthenospermia.
Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility
Ubiquinol-antioxidant blend improved sperm density, antioxidant status, and led to pregnancies in partners of treated infertile men.
The Effect of Antioxidants on Sperm Quality Parameters and Pregnancy Rates for Idiopathic Male Infertility
Coenzyme Q10 significantly improved sperm motility and concentration, though not pregnancy rates, in idiopathic male infertility meta-analysis.
Examining the Effects of Nutrient Supplementation on Metabolic Pathways via Mitochondrial Ferredoxin in Aging Ovaries
Ubiquinol-based supplementation improved ovarian metabolism and oocyte quality via FDX1 activation in women with aging ovaries.
Association of Coenzyme Q10 with Premature Ovarian Insufficiency
Low Coenzyme Q10 levels were linked to increased risk of premature ovarian insufficiency in this case–control study.
Ovarian Aging: Mechanisms and Intervention Strategies
Highlights how mitochondrial dysfunction and oxidative stress drive ovarian aging, with interventions targeting these pathways offering future fertility potential.
Pretreatment with Coenzyme Q10 Improves Ovarian Response and Embryo Quality in Low-Prognosis Young Women with Decreased Ovarian Reserve
Coenzyme Q10 pretreatment improved ovarian response, embryo quality, and reduced IVF cycle cancellations in women with diminished ovarian reserve.
Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality?
Coenzyme Q10 may enhance oocyte mitochondrial function,
The Impact of Two Doses of Coenzyme Q10 on Semen Parameters and Antioxidant Status in Men with Idiopathic Oligoasthenoteratozoospermia
Coenzyme Q10 improved sperm parameters and antioxidant status in a dose-dependent manner in men with idiopathic infertility.